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CodexBiosolutions为学术和政府研究机构，制药和生物技术行业提供基于细胞的测定产品和服务。该公司总部位于马里兰州的I-270高科技走廊。CodexBiosolution的核心产品是ACTOne细胞系和膜潜在试剂盒，这些产品已获得BD Biosciences的许可。我们还开发了其他新的基于电池的产品，以满足各种客户的需求。
ACTOne技术是同类产品中一个以高通量格式提供细胞内cAMP变化的实时信息而无需细胞裂解步骤的技术。该测定法可用于含有专有外源环核苷酸门控（CNG）通道的细胞系。该通道被升高的细胞内cAMP水平激活，导致离子通量（通常可由钙反应性染料检测到）和细胞膜去极化，而荧光膜电势（MP）染料可以检测到。ACTOne cAMP分析可通过FLIPR或荧光酶标仪读取细胞内cAMP变化的终点和动力学。这是一种简单的均相测定法，仅涉及染料和化合物的添加步骤，可轻松在高通量环境中实施。
CodexBiosolutions产品目录
| Product Name | Product No | Product Details |
|---|---|---|
| ACTOne Gi-GPCRs | CB-80300-XXX | ACTOne GPCR cell lines |
| ACTOne Gs-GPCRs | CB-80200-XXX | ACTOne GPCR cell lines |
| ACTOne Membrane Potential Dye Kit (10-plate) | CB-80500-201 | For ACTOne GPCR and PDE cell based assays |
| ACTOne Membrane Potential Dye Kit (100-plate) | CB-80500-211 | For ACTOne GPCR and PDE cell based assays |
| ACTOne PDE10A (cAMP) | CB-81200-102 | PDE10A cell line (cAMP) |
| ACTOne PDE1B (cAMP) | CB-81200-103 | PDE1B cell line (cAMP) |
| ACTOne PDE1C (cAMP) | CB-81200-104 | PDE1C (cAMP) cell line |
| ACTOne PDE4A (cAMP) | CB-81200-105 | PDE4A (cAMP) cell line |
| ACTOne-PDE1A (cAMP) | CB-81200-110 | PDE1A (cAMP) cell line |
| ACTOne-PDE1A (cGMP) | CB-81300-106 | <span new="\"\\"\"'""'\"\\"\"" zh-cn;="\"\\"\"'""'\"\\"\"" en-us;="\"\\"\"'""'\"\\"\"" 11pt;="\"\\"\"'""'\"\\"\"" roman","serif";="\"\\"\"'""'\"\\"\"" "times="\"\\"\"'""'\"\\"\"" roman";="\"\\"\"'""'\"\\"\"" ar-sa;'="\"\\"\"'""'\"\\"\"">PDE1A (cGMP) cell line |
| ACTOne-PDE1B (cGMP) | CB-81300-102 | PDE1B (cGMP) cell line |
| ACTOne-PDE1C (cGMP) | CB-81300-104 | PDE1C (cGMP) cell line |
| ACTOne-PDE2A (cAMP) | CB-81200-101 | PDE2A cell line (cAMP) |
| ACTOne-PDE4 (cAMP) | CB-81200-100 | PDE4 cell line (cAMP) |
| ACTOne-PDE4B (cAMP) | CB-81200-106 | PDE4B (cAMP) cell line |
| ACTOne-PDE4D (cAMP) | CB-81200-107 | PDE4D (cAMP) cell line |
| ACTOne-PDE5A (cGMP) | CB-81300-103 | PDE5A (cGMP) cell line |
| ACTOne-PDE9 (cGMP) | CB-81300-101 | PDE9 (cGMP) cell line |
| Adenosine A1 Receptor | CB-80300-212 | ACTOne-Gi GPCR Cell Line |
| Adenosine A2a Receptor | CB-80200-261 | ACTOne-Gs GPCR Cell Line |
| Adenosine A2b Receptor | CB-80200-260 | ACTOne-Gs GPCR Cell Line |
| Adenosine A3 Receptor | CB-80300-232 | ACTOne-Gi GPCR Cell Line |
| Adenylate Cyclase Activating Polypeptide 1Receptor (ADCYAP1R1) | CB-80200-234 | ACTOne-Gs GPCR Cell Line |
| Adrenergic receptor beta 1 (ADRB1) | CB-80200-272 | ACTOne-Gs GPCR Cell Line |
| Amylin 3 Receptor | CB-80200-271 | ACTOne-Gs GPCR Cell Line |
| Angiotensin Receptor-like 1 | CB-80300-267 | ACTOne-Gi GPCR Cell Line |
| Arginine Vasopressin 2 Receptor (AVPR2) | CB-80200-246 | ACTOne-Gs GPCR Cell Line |
| Beta-2 Adrenergic Receptor | CB-80200-253 | ACTOne-Gs GPCR Cell Line |
| Calcitonin Receptor (CALCR) | CB-80200-258 | ACTOne-Gs GPCR Cell Line |
| Calcitonin-like Receptor (CALCRL) | CB-80200-251 | ACTOne-Gs GPCR Cell Line |
| Cannabinoid Receptor 1 (CB1) | CB-80300-205 | ACTOne-Gi GPCR Cell Line |
| Cannabinoid Receptor 2 (CB2) | CB-80300-225 | ACTOne-Gi GPCR Cell Line |
| Chemokine (C-C motif) Receptor 5 (CCR5) | CB-80300-213 | ACTOne-Gi GPCR Cell Line |
| Chemokine (C-X-C motif) Receptor 4 (CXCR4) | CB-80300-265 | ACTOne-Gi GPCR Cell Line |
| Corticotropin Releasing Hormone Receptor 1 (CRHR1) | CB-80200-249 | ACTOne-Gs GPCR Cell Line |
| Corticotropin Releasing Hormone Receptor 2 (CRHR2) | CB-80200-233 | ACTOne-Gs GPCR Cell Line |
| Dopamine Receptor 1 (DRD1) | CB-80200-218 | ACTOne-Gs GPCR Cell Line |
| Dopamine Receptor 2 (DRD2) | CB-80300-206 | ACTOne-Gi GPCR Cell Line |
| Dopamine Receptor 5 (DRD5) | CB-80200-222 | ACTOne-Gs GPCR Cell Line |
| Follicle Stimulating Hormone Receptor (FSHR) | CB-80200-236 | ACTOne-Gs GPCR Cell Line |
| Gastric Inhibitor Peptide Receptor (GIPR) | CB-80200-221 | ACTOne-Gs GPCR Cell Line |
| Glucagon Receptor (GCGR) | CB-80200-217 | ACTOne-Gs GPCR Cell Line. |
| Glucagon-like Receptor 1 (GLP1R) | CB-80200-248 | ACTOne-Gs GPCR Cell Line |
| Glucagon-like Receptor 2 (GLP2R) | CB-80200-241 | ACTOne-Gs GPCR Cell Line |
| Glutamate Receptor, Metabotropic 2 | CB-80300-262 | ACTOne-Gi GPCR Cell Line |
| Glutamate Receptor, Metabotropic 4 | CB-80300-269 | ACTOne-Gi GPCR Cell Line |
| Glutamate Receptor, Metabotropic 7 | CB-80300-259 | ACTOne-Gi GPCR Cell Line |
| Glutamate Receptor, Metabotropic 8 | CB-80300-239 | ACTOne-Gi GPCR Cell Line |
| GPR119 | CB-80200-274 | ACTOne-Gs GPCR Cell Line |
| Luteinizing hormone/Choriogonadotropin receptor (LHCGR) | CB-80200-275 | ACTOne-Gs GPCR Cell Line |
| Melanin Concentrating Hormone Receptor 1 (MCHR1) | CB-80300-214 | ACTOne-Gi GPCR Cell Line |
| Melanocortin 1 Receptor (MC1R) | CB-80200-257 | ACTOne-Gs GPCR Cell Line |
| Melanocortin 3 Receptor (MC3R) | CB-80200-243 | ACTOne-Gs GPCR Cell Line |
| Melanocortin 4 Receptor (MC4R) | CB-80200-211 | ACTOne-Gs GPCR Cell Line |
| Melanocortin 5 Receptor (MC5R) | CB-80200-215 | ActOne-Gs GPCR Cell Line |
| Neuropeptide Y Receptor Y1 (NPY1R) | CB-80300-244 | ACTOne-Gi GPCR Cell Line |
| Neuropeptide Y Receptor Y2 (NPY2R) | CB-80300-245 | ACTOne-Gi GPCR Cell Line |
| Neuropeptide Y Receptor Y4 (NPY4R) | CB-80300-270 | ACTOne-Gi GPCR Cell Line |
| Neuropeptide Y Receptor Y5 (NPY5R) | CB-80300-280 | ACTOne-Gi GPCR Cell Line |
| Opiate Receptor-like 1 (ORL1) | CB-80300-266 | ACTOne-Gi GPCR Cell Line |
| Opioid receptor, delta 1 | CB-80300-279 | ACTOne-Gi GPCR Cell Line |
| Opioid receptor, kappa 1 | CB-80300-230 | ACTOne-Gi GPCR Cell Line |
| Opioid receptor, Mu | CB-80300-268 | ACTOne-Gi GPCR Cell Line |
| Parathyroid Hormone Receptor 1 (PTHR1) | CB-80200-216 | ACTOne-Gs GPCR Cell Line |
| Parathyroid Hormone Receptor 2 (PTHR2) | CB-80200-228 | ACTOne-Gs GPCR Cell Line |
| Prostaglandin D Receptor 2 (PTGDR2) | CB-80200-255 | ACTOne-Gs GPCR Cell Line |
| Prostaglandin E Receptor 4 (PTGER4) | CB-80200-219 | ACTOne-Gs GPCR Cell Line |
| Prostaglandin I2 Receptor (PTGIR) | CB-80200-247 | ACTOne-Gs GPCR Cell Line |
| PTGER2 (EP2) | CB-80200-256 | ACTOne-Gs GPCR Cell Line |
| Secretin Receptor (SCTR) | CB-80200-235 | ACTOne-Gs GPCR Cell Line |
| Serotonin Receptor 1A (HTR1A) | CB-80300-277 | ACTOne-Gi GPCR Cell Line |
| Serotonin Receptor 1F (HTR1F) | CB-80300-276 | ACTOne-Gi GPCR Cell Line |
| Serotonin Receptor 4 (HTR4) | CB-80200-231 | ACT)ne-Gs GPCR Cell Line |
| Serotonin Receptor 6 (HTR6) | CB-80200-237 | ACTOne-Gs GPCR Cell Line |
| Serotonin Receptor Receptor 7 (HTR7) | CB-80200-240 | ACTOne-Gs GPCR Cell Line |
| Somatostatin Receptor 5 (SSTR5) | CB-80300-207 | ACTOne-Gi GPCR Cell Line |
| Sphingolipid G-protein-coupled receptor 1 (EDG1) | CB-80300-254 | ACTOne-Gi GPCR Cell Line |
| TGR5 | CB-80200-275 | ACTOne-Gs GPCR Cell Line |
| Thyroid Stimulating Hormone Receptor (TSHR) | CB-80200-242 | ACTOne-Gs GPCR Cell Line |
| Vasoactive Intestinal Peptide Receptor 1 (VIPR1) | CB-80200-220 | ACTOne-Gs GPCR Cell Line. |
| Vasoactive Intestinal Peptide Receptor 2 (VIPR2) | CB-80200-209 | ACTOne-Gs GPCR Cell Line. |
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